About OsteoKing

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James, Atlanta, USA
"I would definitely recommend Osteoking for any AVN conditions someone is experiencing. I developed AVN in 2012 after steroid shots for multiple sinus infections and tonsillitis. The steroids caused meet to get AVN in my left hip and at the point I noticed it I was still very early on in the stages. I was at stage one. I found Osteoking online and decided to give it a try. I had severe sharp pains in my hip and could barely walk without a limp. I begin taking Osteoking a few weeks after finding out I had AVN and the conditions begin improving greatly. The pain and limp went away after about 3 months of taking Osteoking and I was pain free and back walking and during activities like cutting the grass and exercising with no pain about 6 months to a year later. At that time I had gone to get an X-Ray and the doctor said I was still in the early phases and that the condition had not gotten worse. I do think that Osteoking was the main reason for my condition not worsening. I think I would have healed completely, but unfortunately, I had to have a surgery to have my tonsils removed and i was put back on steroids, Prednisone, and after stopping the Osteoking during the surgery, I felt the pain coming back from the steroids. So I had gone back to the doctor. At this point the AVN started to get worse at early stage two. So I had a core decompression surgery on my left hip and two weeks after the surgery, I begin taking Osteoking again and begin exercising on a stationary bike with great resistance a few weeks after my surgery. It has been 9 months post-surgery and my X-ray shows that new bone has formed and no collapse has occurred. The femur bone looks healthy and rounds and I am completely pain free. I have not taken pain medicine since the second week of my surgery. I totally believe that Osteoking was the main reason why I never had a collapse and that new bone is forming and my hip is fully recovering. I have one more checkup in October for a year follow-up, but Osteoking has saved me from losing my hip and recovering from AVN. I would definitely recommend this product. I have been pain free for about nine months and don't even take any other pain medicine. I have returned to all activities and exercise, with the exception of running. I do believe that Osteoking, exercise, diet, and Prayer have been the key to my recovery. I still take Osteoking now and will continue to take a maintenance dose to make sure this doesn't happen again. Thanks Osteoking for your product!"
Product Researches
In order to explore its mechanism of the effects, extensive studies and researches have been conducted in foremost level of biochemistry, histomorphology, molecular biology for OsteoKing. The results show that OsteoKing can reduce blood viscosity, improve hemodynamics, reduce internal pressure of bone, improve blood supply, reduce blood fat concentration, reduce the formation of fat embolism and promote the genetic expression of endogenous VEGF(Vascular endothelial growth factor), cbf a1(core binding factor a-1) and BMP-2(Bone morphogenetic proteins-2). It can also strengthen the activity of bone cells and inhibit osteoclast cells.


Observation with optical microscope, transmission electron microscope and scanning electron microscope, the results showed



Necrotic bone cells are less in the OsteoKing group, more osteoblasts and osteoclasts, new bone cells and bone matrix are appeared as well as calcium deposit occurs. The results observed with scanning electron microscope indicate that more osteoblasts appeared on the surface of bone trabecula. OsteoKing group has remarkable superiority compares with model group.


Promoting the formation of blood vessel by promoting the genetic expression of endogenous VEGF, effectively improve the activity of osteoblasts and speed the formation of bone cells.


VEGF (Vascular endothelial growth factor) is very closely related to bone repair and plays a very important role in the formation and repair of bone. (Lieberman JR, et al. Instr Course Lect, 2003; 52:337-55. ?Carano RA, et al. Drug Discov Today. 2003, 8(21): 980-989.?Yancopoulos GD,et al. Nature. 2000, 407(6801):242-248. Review.)


Tested through the methods of immunohistochemistry, hybridization in situ, real-time fluorescent fixed quantity and PCR and verified each other then draw the same conclusion that OsteoKing can promote the expression of endogenous VEGF in the necrotic femoral head and increase the expression volume significantly. Compared with Model group, the difference has statistics significance (p<0.05).


Promoting the development, differentiation, regulation of osteoblasts and bone calcification by boosting the genetic of cbf a1.


cbf a1 (core binding factor ?1) gene is osteogenesis specificity transcription activation factor, It plays a very important role during the development and differentiation of the osteoblast and the bone formation.(Ducy P, et al. Cell, 1997, 89(5):747~754.?Komori T, et al. Cell, 1997, 89(5):755-764.?He J, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2004, 97(2):239-245.)


Tested through the methods of immunohistochemistry, hybridization in situ, real-time fluorescent fixed quantity and PCR and verified each other then draw the same conclusion that OsteoKing can promote the repair of necrotic bone through promoting the expression of cbf ?1 in the necrotic femoral head and increase the expression volume significantly. Compared with the model group, the difference has statistics significance (p<0.05).


Inducting ossification and stimulating the formation of bone cells by boosting the genetic of BMP-2.


BMP-2 (Bone morphogenetic proteins-2) has very powerful activity in inducting ossification (Wozney JM, et al. Science, 1988, 242(4885): 1528-1534.?Croteau S,et al. Orthopedics, 1999, 22(7):686-695.?Shore EM, et al. Clin Orthop, 1995, (311):199-209.)


Tested through the methods of immunohistochemistry, hybridization in situ, real-time fluorescent fixed quantity and PCR and verified each other then draw the same conclusion that OsteoKing can promote the repair of necrotic bone through promoting the expression of BMP-2 in the necrotic femoral head and increase the expression volume significantly. Compared with the model group, the difference has statistics significance (p<0.05).


The researches of OsteoKing are performed with the latest modern methods and receive the scientific data, from many angles and aspects to analysis the mechanism of the effects of OsteoKing deeply to the genetic level. Those provide solid scientific data for the end user application. It is the top choice for maintaining the human bone health.


OsteoKing has also been tested and applied on more than ten thousands of clinical cases in many hospitals in China, including the Shanghai Sixth People’s Hospital, Beijing Ji Shui Tang Hospital, Beijing No. 301 Hospital of PLA, Affiliated Hospital of Beijing Medical University, Affiliated Hospital of Guangzhou Sun Yat Sen Medical University, Guangzhou Southern Hospital, Affiliated Hospital of Shandong Traditional Chinese Medical University, Hubei Tong Ji Hospital, Hubei Friendship Hospital, Affiliated Hospital of Zhejiang University, Sichuan Provincial People’s Hospital, Yunnan Provincial People’s Hospital, Affiliated Hospital of Kunming Medical College, the General Hospital of Chengdu Military District, Affiliated Hospital of Harbin Medical University, Affiliated Hospital of the Third Military Medical University. OsteoKing has also been used by the users in the US and Europe and has been highly recommended by the doctors and the patients. It was called "magic herbal product" by the user from UK and "water of life" by the user from Turkey.